The 2010 Western Kentucky Hilltoppers football team represented Western Kentucky University (WKU) in the 2010 NCAA Division I FBS football season. The Hilltoppers were led by first-year head coach Willie Taggart and played their home games at Houchens Industries–L. T. Smith Stadium. They are members of the Sun Belt Conference.
The Hilltoppers finished the season with a 2–10 record, and 2–6 in Sun Belt play which placed them in last place. The 2 wins by the team marked the first and second victories as members of the Sun Belt.
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